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Research Associate, University of Southern California, Keck School of Medicine (2009-2012)
충남대학교 의과학연구센터 전임 연구 교수 (2012-2013)
2. 주요 연구 분야
A) 결핵 및 톡소포자충증의 감염/병인 기전 연구를 수행하여, 병원체와 숙주 세포의 상호 작용 이해를 통한 감염성 질환의 예방 및 치료 기반 기술 개발
B) 세포내 활성 산소 유래 분자 면역 조절 기전 연구를 수행하여, 감염성 질환 (결핵, 톡소포자충증, 리스테리아증, 캔디다증, 독감, 패혈증 등) 및 자가 면역 질환 (염증성 대장염, 류마티스 관절염 등) 동물 모델을 이용한 면역 조절 치료 기술 개발
3. 대표 연구업적 (논문)
1. Autophagy Protein Rubicon Mediates Phagocytic NADPH Oxidase Activation in Response to Microbial Infection or TLR Stimulation. Cell Host & Microbe. 2012 Mar 15;11(3):264-76
2. The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy. Autophagy. 2014 May 1;10(5):785-802.
3. Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome. Nat Commun. 2015 Feb 6;6:6115.
B) Cancer big data analysis for precision medicine
C) Integration between genotype and phenotype
D) Molecular marker identification with Genomic data
3. 대표 연구업적 (논문)
1. Protein-gene Expression Nexus: Comprehensive characterization of human cancer cell lines with proteogenomic analysis. Computational and Structural Biotechnology Journal. 2021, 19:4759. https://doi.org/10.1016/j.csbj.2021.08.022
2. Integrated molecular characterization of adult soft tissue sarcoma for therapeutic targets. BMC Med Genet. 2018 Dec 31;19(Suppl 1):216. doi: 10.1186/s12881-018-0722-6.
3. RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer. Nat Commun. 2018 Oct 25;9(1):4439. doi: 10.1038/s41467-018-06747-4.
4. Construction of a Transcriptome-Driven Network at the Early Stage of Infection with Influenza A H1N1 in Human Lung Alveolar Epithelial Cells. Biomol Ther (Seoul). 2018 May 1;26(3):290-297. doi: 10.4062/biomolther.2017.240.
5. ASpedia: a comprehensive encyclopedia of human alternative splicing. Nucleic Acids Res. 2018 Jan 4;46(D1):D58-D63. doi: 10.1093/nar/gkx1014.
6. Sporadic Early-onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations but Low Frequency of Somatic RHOA Mutations Compared with Late-onset Cancers. Gastroenterology. 2017 Aug;153(2):536-549.e26. doi: 10.1053/j.gastro.2017.05.012.
1. Association analysis of toluene exposure time with high-throughput mRNA expressions and methylation patterns using in vivo samples. Environmental Research 146:59-64 (2016).
2. Fluorescence melting curve analysis using self-quenching dual-labeled PNA probes for simultaneous identifying multiple DNA sequences. Analytical Biochemistry 484:143-147 (2015).
3. The core meiotic transcriptome in budding yeasts. Nature Genetics 6(4):415-423 (2000)