염증은 세균과 바이러스의 감염을 방어하는 수단이고 상처를 아물게하는 과정에서 조직의 재건을 돕는 우리몸의 중요한 면역 반응이다. 하지만, 이러한 염증 반응이 제대로 조절되지않고 너무 과하게 지속되면 암, 당뇨, 심뇌혈관질환과 같은 염증성 질환으로 나타나게된다. 본 실험실은 염증을 동반한 많은 질병들 에서 여러 신호전달 과정을 분석하고 각각의 신호전달 시스템의 병리학적 기능을 이해하는 것이 목표이다.

Inflammation is a response of the immune system to infection and tissue injury. Although it is a protective and healing process, inflammation may cause more damage than the inciting events if its magnitude and duration are not finely controlled. An excessive and unrestrained inflammatory response underlies diverse forms of chronic inflammatory diseases such as cancer, diabetes, and cardio/neuro vascular disease. We aim to understand the pathophysiological roles of diverse signaling pathways in inflammation associated diseases.

Selected Publications

1. Jaco I*, Annibaldi A*, Lalaoui N*, Wilson R*, Tenev T, Laurien L, Kim C, Jamal K, John SW, Liccardi G, Chau D, Murphy JM, Brumatti G, Feltham R, Pasparakis M, Silke J, Meier P
   *These authors contributed equally to this work.
   MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.
   Mol Cell. 2017 Jun 1; 66(5):698-710
2. Lin J*, Kumari S*, Kim C*, Van TM, Wachsmuth L, Polykratis A, Pasparakis M
   *Co-first authors. The order of appearance of first authors was determined by a draw.
   RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.
   Nature. 2016 Dec 1; 540(7631):124-128
3. Dannappel M*, Vlantis K*, Kumari S*, Polykratis A*, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M
   *These authors contributed equally to this work.
   RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.
   Nature. 2014 Sep 4; 513(7516):90-4
4. Kim C, Pasparakis M
   Epidermal p65/NF-κB signaling is essential for skin carcinogenesis.
   EMBO Mol Med. 2014 Jun 21; 6(7):970-83
5. Kim C, Sano Y, Todorova K, Carlson B, Arpa L, Celada A, Lawrence T, Otsu K, Brissette J, Arthur JA & Park JM
   The kinase p38α serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression.
   Nat Immunol. 2008 Sep; 9(9):1019-1027
6. Kim C, Wilcox-Adelman S, Sano Y, Tang W, Collier RJ and Park JM
   Anti-inflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus.
   Proc Natl Acad Sci U S A. 2008 Apr 22; 105(16): 6150-6155
7. Kim C, Gajendran N, Mittruecker H, Weiwad N, Song Y, Hurwitz R, Wilmanns M, Fisher G, Kaufmann SH
   Human α-defensins neutralize anthrax lethal toxin and protect against its fatal consequences.
   Proc Natl Acad Sci U S A. 2005 Mar 29; 102(13): 4830-4835